منابع مشابه
Notch signaling promotes nephrogenesis by downregulating Six2
During nephrogenesis, multipotent mesenchymal nephron progenitors develop into distinct epithelial segments. Each nephron segment has distinct cell types and physiological function. In the current model of kidney development, Notch signaling promotes the formation of proximal tubules and represses the formation of distal tubules. Here, we present a novel role of Notch in nephrogenesis. We show ...
متن کاملCalcium/NFAT signalling promotes early nephrogenesis
A number of Wnt genes are expressed during, and are known to be essential for, early kidney development. It is typically assumed that their products will act through the canonical β-catenin signalling pathway. We have found evidence that suggests canonical Wnt signalling is not active in the early nephrogenic metanephric mesenchyme, but instead provide expressional and functional evidence that ...
متن کاملGenetic dissection of cadherin function during nephrogenesis.
The distinct expression of R-cadherin in the induced aggregating metanephric mesenchyme suggests that it may regulate the mesenchymal-epithelial transition during kidney development. To address whether R-cadherin is required for kidney ontogeny, R-cadherin-deficient mice were generated. These mice appeared to be healthy and were fertile, demonstrating that R-cadherin is not essential for embryo...
متن کاملS08-13 Tissue interactions in Drosophila nephrogenesis
intracellular components have been identified in both invertebrate and vertebrate, extracellular regulation that allows the morphogenesis cell mass maintaining the epithelial integrity is largely unknown. Here, we present Nectin2, a cell adhesion molecule belonging to the immunoglobulin family has an essential role in the apical constriction. Nectin2 expression is spatially and temporally regul...
متن کاملNeonatal hyperoxia: effects on nephrogenesis and long-term glomerular structure.
Preterm neonates are born while nephrogenesis is ongoing and are commonly exposed to factors in the extrauterine environment that may impair renal development. Supplemental oxygen therapy exposes the preterm infant to a hyperoxic environment that may induce oxidative stress. Our aim was to determine the immediate and long-term effects of exposure to hyperoxia, during the period of postnatal nep...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genome Biology
سال: 2001
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20010504-02